Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

Journal article

Understanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics.

Authors: Aggarwal, D; Warne, B; Jahun, AS; Hamilton, WL; Fieldman, T

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Nature Communications
• Volume: 13
• Issue: 1
• Pages: 751
• Publication date: 2022-02-08
• DOI: 10.1038/s41467-021-27942-w
• EISSN: 2041-1723
• ISSN: 2041-1723
• Language: English
• Keywords: Pandemic; Contact tracing