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MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop.

Abstract:

Prostaglandin production is catalyzed by cyclooxygenase 2 (cox-2). We demonstrate here that MSK1 and MSK2 (MSK1/2) can exert control on the induction of cox-2 mRNA by Toll-like receptor (TLR) agonists. In the initial phase of cox-2 induction, MSK1/2 knockout macrophages confirmed a role for MSK in the positive regulation of transcription. However, at later time points both lipopolysaccharide (LPS)-induced prostaglandin and cox-2 protein levels were increased in MSK1/2 knockout. Further analys...

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Publication status:
Published

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Publisher copy:
10.1128/MCB.01690-12

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Journal:
Molecular and cellular biology
Volume:
33
Issue:
7
Pages:
1456-1467
Publication date:
2013-04-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:6bf457c3-e9ce-4b9f-8bc8-4010d6b20680
Source identifiers:
384216
Local pid:
pubs:384216

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