Journal article

Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin

Abstract:: Biomimetic intramolecular aldol reactions on oxazolidine templates derived from serine may be used to generate densely functionalised pyroglutamates, which are simpler mimics of the right hand side of oxazolomycin. Some of the compounds from this sequence exhibit in vivo activity against S. aureus and E. coli, suggesting that pyroglutamate scaffolds may be useful templates for the development of novel antibacterials, and cheminformatic analysis has been used to provide some structure-activity data.

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Angelov, P., Chau, Y., Fryer, P., Moloney, M., Thompson, A., & Trippier, P. (2012). Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin. Organic and Biomolecular Chemistry, 10(17), 3472–3485.

MLA Style

Angelov, P., et al. “Biomimetic Synthesis, Antibacterial Activity and Structure-Activity Properties of the Pyroglutamate Core of Oxazolomycin.” Organic and Biomolecular Chemistry, vol. 10, no. 17, Royal Society of Chemistry, 2012, pp. 3472–85.

Chicago Style

Angelov, P, Y Chau, P Fryer, M Moloney, A Thompson, and P Trippier. 2012. “Biomimetic Synthesis, Antibacterial Activity and Structure-Activity Properties of the Pyroglutamate Core of Oxazolomycin.” Organic and Biomolecular Chemistry 10 (17): 3472–85.
Share
Print

Access Document

Publisher copy:: 10.1039/c2ob00042c

Authors

+ Angelov, P More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Role:: Author

+ Chau, Y More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Role:: Author

+ Fryer, P More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Role:: Author

+ Moloney, M More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Thompson, A More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Inorganic Chemistry
Role:: Author

More authors...

Publisher:: Royal Society of Chemistry
Journal:: Organic and Biomolecular Chemistry More from this journal
Volume:: 10
Issue:: 17
Pages:: 3472-3485
Publication date:: 2012-02-29
Acceptance date:: 2012-02-28
DOI:: 10.1039/c2ob00042c
EISSN:: 1477-0539
ISSN:: 1477-0520

Language:: English
Keywords:: Staphylococcus aureus

Models, Molecular

Structure-Activity Relationship

Biomimetics

Escherichia coli

Anti-Bacterial Agents

Oxazoles

Spiro Compounds

Molecular Conformation

Pyrrolidonecarboxylic Acid
Pubs id:: pubs:320369
UUID:: uuid:6bdf2e52-9fa3-409c-929b-9c352c93baa2
Local pid:: pubs:320369
Source identifiers:: 320369
Deposit date:: 2012-12-19

Terms of use

Copyright holder:: Royal Society of Chemistry
Copyright date:: 2012
Notes:: © The Royal Society of Chemistry 2012

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP