Journal article

Enzymatic kinetic resolution by addition of oxygen

Abstract:: Kinetic resolution using biocatalysis has proven to be an excellent complementary technique to traditional asymmetric catalysis for the production of enantioenriched compounds. Resolution using oxidative enzymes produces valuable oxygenated structures for use in synthetic route development. This Minireview focuses on enzymes which catalyse the insertion of an oxygen atom into the substrate and, in so doing, can achieve oxidative kinetic resolution. The Baeyer–Villiger rearrangement, epoxidation, and hydroxylation are included, and biological advancements in enzyme development, and applications of these key enantioenriched intermediates in natural product synthesis are discussed.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Harwood, L. A., Wong, L. L., & Robertson, J. (2020). Enzymatic kinetic resolution by addition of oxygen. Angewandte Chemie International Edition, 60(9), 4434–4447.

MLA Style

Harwood, L. A., et al. “Enzymatic Kinetic Resolution by Addition of Oxygen.” Angewandte Chemie International Edition, vol. 60, no. 9, Wiley, 2020, pp. 4434–47.

Chicago Style

Harwood, LA, LL Wong, and J Robertson. 2020. “Enzymatic Kinetic Resolution by Addition of Oxygen.” Angewandte Chemie International Edition 60 (9): 4434–47.
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Files:: Harwood_et_al_2021_Enzymatic_kinetic_resolution.pdf

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Publisher copy:: 10.1002/anie.202011468

Authors

+ Harwood, LA More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Role:: Author

+ Wong, LL More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Role:: Author
ORCID:: 0000-0003-4875-1092

+ Robertson, J More by this author

Institution:: University of Oxford
Role:: Author

Publisher:: Wiley
Journal:: Angewandte Chemie International Edition More from this journal
Volume:: 60
Issue:: 9
Pages:: 4434-4447
Publication date:: 2020-10-10
Acceptance date:: 2020-10-08
DOI:: 10.1002/anie.202011468
EISSN:: 1521-3773
ISSN:: 1433-7851

Language:: English
Keywords:: FFR
Pubs id:: 1137410
Local pid:: pubs:1137410
Deposit date:: 2020-10-13

Terms of use

Copyright holder:: Wiley
Copyright date:: 2020
Rights statement:: © 2020 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Licence:: CC Attribution (CC BY)

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