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Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study

Abstract:

Aims: To examine the changes in coronary, all-cause, and cancer mortality in patients with heterozygous familial hypercholesterolaemia (FH) before and after lipid-lowering therapy with statins. Methods and results: A total of 3382 patients (1650 men) aged <80 years were recruited from 21 lipid clinics in the United Kingdom and followed prospectively between 1980 and 2006 for 46580 person-years. There were 370 deaths, including 190 from coronary heart disease (CHD) and 90 from cancer. The s...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/eurheartj/ehn422

Authors


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Institution:
University of Oxford
Research group:
"NIHR School of Primary Care Research"
Department:
Medical Sciences Division - Public Health - Primary Care
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Institution:
"Royal Free and University College London Medical School, London, UK"
Department:
Centre for Cardiovascular Genetics,British Heart Foundation Laboratories
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Institution:
"Royal Free and University College London Medical School, London, UK"
Department:
Department of Medicine
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Institution:
"The Shrewsbury and Telford Hospital NHS Trust, Princess Royal Hospital, Telford, UK"
Department:
Department of Clinical Biochemistry
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Institution:
"University Hospital of Wales, Cardiff, UK"
Department:
Department of Medical Biochemistry and Immunology
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Funding agency for:
Andrew Neil
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Funding agency for:
Steve E. Humphries
Pfizer Ltd. More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
European heart journal Journal website
Volume:
29
Issue:
21
Pages:
2625-2633
Publication date:
2008-11-05
DOI:
EISSN:
1522-9645
ISSN:
0195-668x
URN:
uuid:6bd355ee-2858-43fe-851a-7dc8ecf35243
Local pid:
ora:2439

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