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The selective CCK-B receptor antagonist L-365,260 enhances morphine analgesia and prevents morphine tolerance in the rat.

Abstract:

The effects of the selective CCK-A antagonist L-365,031 and the selective CCK-B antagonist L-365,260 on morphine analgesia and opiate tolerance and dependence in rats were examined. L-365,031 and L-365,260 had no effect on baseline pain thresholds in the radiant heat tail flick test but enhanced analgesia induced by a submaximal dose of morphine (4 mg/kg). Similarly, L-365,260 did not effect pain thresholds in the paw pressure test but enhanced morphine analgesia in this model. Rats injected ...

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Publication status:
Published

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Authors


Dourish, CT More by this author
O'Neill, MF More by this author
Coughlan, J More by this author
Kitchener, SJ More by this author
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Journal:
European journal of pharmacology
Volume:
176
Issue:
1
Pages:
35-44
Publication date:
1990-01-05
DOI:
EISSN:
1879-0712
ISSN:
0014-2999
URN:
uuid:6bc048ef-fa12-44ee-80d1-0d87fdbcad6b
Source identifiers:
13257
Local pid:
pubs:13257

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