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Pharmacokinetics of tacrine hydrochloride in Alzheimer's disease.

Abstract:

The clinical pharmacokinetics of tacrine hydrochloride have been characterized in patients who have Alzheimer's disease. Serum concentrations of the drug and of its probable metabolite were monitored in eight patients after a 25 mg oral dose, in six patients after a 50 mg oral dose, in four patients after repeated administration of 50 mg, and in two patients after a small intravenous dose. Urinary excretion of drug and metabolite for 24 hours was measured in one of the patients who received a...

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Publication status:
Published

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Publisher copy:
10.1038/clpt.1989.199

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Clinical pharmacology and therapeutics
Volume:
46
Issue:
6
Pages:
634-641
Publication date:
1989-12-01
DOI:
EISSN:
1532-6535
ISSN:
0009-9236
Language:
English
Keywords:
Pubs id:
pubs:35205
UUID:
uuid:6bb12c19-59b9-4215-a9e3-e08f505b3a34
Local pid:
pubs:35205
Source identifiers:
35205
Deposit date:
2012-12-19

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