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Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases.

Abstract:

While the oxygen-dependent reversal of lysine N(ɛ)-methylation is well established, the existence of bona fide N(ω)-methylarginine demethylases (RDMs) is controversial. Lysine demethylation, as catalysed by two families of lysine demethylases (the flavin-dependent KDM1 enzymes and the 2-oxoglutarate- and oxygen-dependent JmjC KDMs, respectively), proceeds via oxidation of the N-methyl group, resulting in the release of formaldehyde. Here we report detailed biochemical studies clearly demonstr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms11974

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More from this funder
Name:
British Heart Foundation
Funding agency for:
Kawamura, A
Grant:
Centre of Research Excellence Oxford (RE/13/1/30181
More from this funder
Name:
Royal Society
Funding agency for:
Kawamura, A
Grant:
Centre of Research Excellence Oxford (RE/13/1/30181
More from this funder
Name:
William R. Miller Junior Research Fellowship
Funding agency for:
Hopkinson, R
Grant:
studentships
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Funding agency for:
Walport, L
Hopkinson, R
Grant:
studentships
studentships
More from this funder
Name:
Cancer Research UK
Grant:
C8717/A18245
Publisher:
Nature Publishing Group
Journal:
Nature Communications More from this journal
Volume:
7
Pages:
11974
Publication date:
2016-06-23
Acceptance date:
2016-05-17
DOI:
EISSN:
2041-1723
Language:
English
Pubs id:
pubs:629752
UUID:
uuid:6baa5164-8b08-419a-a342-c8152ad20645
Local pid:
pubs:629752
Source identifiers:
629752
Deposit date:
2016-07-16

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