Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases.
While the oxygen-dependent reversal of lysine N(ɛ)-methylation is well established, the existence of bona fide N(ω)-methylarginine demethylases (RDMs) is controversial. Lysine demethylation, as catalysed by two families of lysine demethylases (the flavin-dependent KDM1 enzymes and the 2-oxoglutarate- and oxygen-dependent JmjC KDMs, respectively), proceeds via oxidation of the N-methyl group, resulting in the release of formaldehyde. Here we report detailed biochemical studies clearly demonstr...Expand abstract
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- © 2016 the Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The final version is available online from Nature Publishing Group at: [10.1038/ncomms11974].
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