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The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Abstract:

Early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic β cells. We show here that exposure to pro-inflammatory cytokines unmasks a marked plasticity of the β-cell regulatory landscape. We expand the repertoire of human islet regulatory elements by mapping stimulus-responsive enhancers linked to changes in the β-cell transcriptome, proteome and 3D chromatin structure. Our data indicates that the β cell ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1038/s41588-019-0524-6

Authors


Publisher:
Springer Nature
Journal:
Nature Genetics More from this journal
Volume:
51
Pages:
1588–1595
Publication date:
2019-11-01
Acceptance date:
2019-06-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Language:
English
Pubs id:
pubs:1030900
UUID:
uuid:6b9b6bc2-faa4-4a9d-ac23-2221759a0d7e
Local pid:
pubs:1030900
Source identifiers:
1030900
Deposit date:
2019-07-10

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