Journal article
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
- Abstract:
-
Early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic β cells. We show here that exposure to pro-inflammatory cytokines unmasks a marked plasticity of the β-cell regulatory landscape. We expand the repertoire of human islet regulatory elements by mapping stimulus-responsive enhancers linked to changes in the β-cell transcriptome, proteome and 3D chromatin structure. Our data indicates that the β cell ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Genetics Journal website
- Volume:
- 51
- Pages:
- 1588–1595
- Publication date:
- 2019-11-01
- Acceptance date:
- 2019-06-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
Item Description
- Language:
- English
- Pubs id:
-
pubs:1030900
- UUID:
-
uuid:6b9b6bc2-faa4-4a9d-ac23-2221759a0d7e
- Local pid:
- pubs:1030900
- Source identifiers:
-
1030900
- Deposit date:
- 2019-07-10
Terms of use
- Copyright holder:
- Ramos-Rodríguez et al.
- Copyright date:
- 2019
- Rights statement:
- © The Author(s), under exclusive licence to Springer Nature America, Inc. 2019
- Notes:
- This is the accepted manuscript version of the article. The final version is available from Springer Nature at: https://doi.org/10.1038/s41588-019-0524-6
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