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Journal article

Enhancing immunotoxin cell-killing activity via combination therapy with ABT-737.

Abstract:

Immunotoxins are antibody-toxin fusion proteins directed to kill cancer cells displaying specific target antigens on their surface. Remarkably, immunotoxins directed to CD22 on hairy cell leukemia have produced complete remissions in approximately 60% of patients enrolled in phase I/II trials. For reasons that are not yet clear, 40% of patients responded less well. In addition, patients with other CD22-positive malignancies have not yet achieved complete remissions. In trying to understand 'r...

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Publication status:
Published

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Journal:
Leukemia and lymphoma
Volume:
52 Suppl 2
Issue:
SUPPL. 2
Pages:
79-81
Publication date:
2011-06-05
DOI:
EISSN:
1029-2403
ISSN:
1042-8194
URN:
uuid:6b7d6ce9-2c69-42bc-9312-d393814eb231
Source identifiers:
141415
Local pid:
pubs:141415

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