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Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

Abstract:

Diffuse intrinsic pontine gliomas (DIPGs) are highly infiltrative malignant glial neoplasms of the ventral pons that, due to their location within the brain, are unsuitable for surgical resection and consequently have a universally dismal clinical outcome. The median survival time is 9-12 months, with neither chemotherapeutic nor targeted agents showing substantial survival benefit in clinical trials in children with these tumors. We report the identification of recurrent activating mutations...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2925

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Publisher:
Nature Publishing Group
Journal:
NATURE GENETICS More from this journal
Volume:
46
Issue:
5
Pages:
457-461
Publication date:
2014-05-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Language:
English
Pubs id:
pubs:465295
UUID:
uuid:6b558c54-7321-4012-8df8-75d42d25b914
Local pid:
pubs:465295
Source identifiers:
465295
Deposit date:
2014-06-17

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