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mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes.

Abstract:

MicroRNAs (miRNAs) silence the expression of target genes post-transcriptionally. Their function is mediated by the Argonaute proteins (AGOs), which colocalize to P-bodies with mRNA degradation enzymes. Mammalian P-bodies are also marked by the GW182 protein, which interacts with the AGOs and is required for miRNA function. We show that depletion of GW182 leads to changes in mRNA expression profiles strikingly similar to those observed in cells depleted of the essential Drosophila miRNA effec...

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Publisher copy:
10.1101/gad.1424106

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Genes and development More from this journal
Volume:
20
Issue:
14
Pages:
1885-1898
Publication date:
2006-07-01
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
Language:
English
Keywords:
Pubs id:
pubs:353654
UUID:
uuid:6b4fe76e-6d9c-4287-8806-45c3ac4dbf04
Local pid:
pubs:353654
Source identifiers:
353654
Deposit date:
2013-11-16

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