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Neutralization of infectivity of diverse R5 clinical isolates of human immunodeficiency virus type 1 by gp120-binding 2'F-RNA aptamers.

Abstract:

Human immunodeficiency virus type 1 (HIV-1) has evolved a number of strategies to resist current antiretroviral drugs and the selection pressures of humoral and cellular adaptive immunity. For example, R5 strains, which use the CCR5 coreceptor for entry and are the dominant viral phenotype for HIV-1 transmission and AIDS pathogenesis, are relatively resistant to neutralization by antibodies, as are other clinical isolates. In order to overcome these adaptations, we raised nucleic acid aptamer...

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Publication status:
Published

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Authors


Schüman, M More by this author
Ibrahim, J More by this author
Sattentau, Q More by this author
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Journal:
Journal of virology
Volume:
77
Issue:
23
Pages:
12692-12698
Publication date:
2003-12-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:6b3d381f-e196-4e75-b6f5-c18e91eb5d9b
Source identifiers:
16598
Local pid:
pubs:16598

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