Journal article
Finding a needle in a haystack: the role of electrostatics in target lipid recognition by PH domains
- Abstract:
-
Interactions between protein domains and lipid molecules play key roles in controlling cell membrane signalling and trafficking. The pleckstrin homology (PH) domain is one of the most widespread, binding specifically to phosphatidylinositol phosphates (PIPs) in cell membranes. PH domains must locate specific PIPs in the presence of a background of approximately 20% anionic lipids within the cytoplasmic leaflet of the plasma membrane. We investigate the mechanism of such recognition via a mult...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Computational Biology Journal website
- Volume:
- 8
- Issue:
- 7
- Pages:
- ARTN e1002617
- Publication date:
- 2012-07-26
- Acceptance date:
- 2012-06-01
- DOI:
- EISSN:
-
1553-7358
- ISSN:
-
1553-734X
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:353338
- UUID:
-
uuid:6b39c303-4245-4674-880f-e6e5062d9735
- Local pid:
- pubs:353338
- Source identifiers:
-
353338
- Deposit date:
- 2013-11-16
Terms of use
- Copyright holder:
- Lumb, Sansom
- Copyright date:
- 2012
- Notes:
- Copyright: © 2012 Lumb, Sansom. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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