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Regulation of tyrosine phosphorylation cascades by phosphatases: What the actions of vanadium teach us

Abstract:

Protein phosphorylation and dephosphorylation regulate much of the machinery of the cell. Emphasis in recent years has swung toward regulation by dephosphorylation. Much current research focuses on protein tyrosine phosphatases. Researchers of cellular regulation use vanadium as a probe because of its unparalleled ability to selectively inhibit protein tyrosine phosphatases at submicromolar concentrations. This review focuses on the biological actions of vanadium relevant to cellular regulato...

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Publication status:
Published

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Publisher copy:
10.1002/jtra.10040
Journal:
JOURNAL OF TRACE ELEMENTS IN EXPERIMENTAL MEDICINE More from this journal
Volume:
16
Issue:
4
Pages:
281-290
Publication date:
2003-01-01
DOI:
EISSN:
1520-670X
ISSN:
0896-548X
Language:
English
Keywords:
Pubs id:
pubs:107907
UUID:
uuid:6b296801-659f-41a7-a1d2-796d85a9f98f
Local pid:
pubs:107907
Source identifiers:
107907
Deposit date:
2012-12-19

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