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EspM2 is a RhoA guanine nucleotide exchange factor

Abstract:

We investigated how the type III secretion system WxxxE effectors EspM2 of enterohaemorrhagic Escherichia coli, which triggers stress fibre formation, and SifA of Salmonella enterica serovar Typhimurium, which is involved in intracellular survival, modulate Rho GTPases. We identified a direct interaction between EspM2 or SifA and nucleotidefree RhoA. Nuclear Magnetic Resonance Spectroscopy revealed that EspM2 has a similar fold to SifA and the guanine nucleotide exchange factor (GEF) effector...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1111/j.1462-5822.2009.01423.x

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Publisher:
Wiley Publisher's website
Journal:
Cellular Microbiology Journal website
Volume:
12
Issue:
5
Pages:
654-664
Publication date:
2010-05-05
DOI:
EISSN:
1462-5822
ISSN:
1462-5814
URN:
uuid:6b0a54b7-4f94-486b-a991-2d13f035cb68
Source identifiers:
176578
Local pid:
pubs:176578
Language:
English

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