An exact nonparametric method for inferring mosaic structure in sequence triplets.

Journal article

Statistical tests for detecting mosaic structure or recombination among nucleotide sequences usually rely on identifying a pattern or a signal that would be unlikely to appear under clonal reproduction. Dozens of such tests have been described, but many are hampered by long running times, confounding of selection and recombination, and/or inability to isolate the mosaic-producing event. We introduce a test that is exact, nonparametric, rapidly computable, free of the infinite-sites assumption...

Expand abstract

Authors: Boni, M; Posada, D; Feldman, M

• Publication status: Published
• Journal: Genetics
• Volume: 176
• Issue: 2
• Pages: 1035-1047
• Publication date: 2007-06-01
• DOI: 10.1534/genetics.106.068874
• EISSN: 1943-2631
• ISSN: 0016-6731
• Language: English
• Keywords: Child; Triplets; Adult; Linkage Disequilibrium; Genetic Variation; Statistics, Nonparametric; Recombination, Genetic; Female; Male; Mutation; Humans; Mosaicism; Models, Genetic