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Determination of pore-lining residues in the hepatitis C virus p7 protein.

Abstract:

The p7 protein from hepatitis C virus is critical for the assembly and secretion of infectious virus, making it an attractive drug target. It is thought to be a viroporin with a demonstrated ion channel activity when reconstituted into planar lipid bilayers. Electron microscopy experiments suggest that p7 oligomers coexist as hexamers and heptamers. Proposed models of p7 oligomers assume the N-terminal helix to be the pore lining helix. Here, we demonstrate, via electrophysiology, that Cu(2+)...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.bpj.2008.10.004

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Wellcome Trust More from this funder
Overseas Research Students Awards Scheme More from this funder
Publisher:
Cell Press Publisher's website
Journal:
Biophysical Journal Journal website
Volume:
96
Issue:
2
Pages:
L10-L12
Publication date:
2009-01-22
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:6b0660b4-fc0d-4b1c-9533-095df9f03681
Source identifiers:
99837
Local pid:
pubs:99837

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