Serum insulin-like growth factor-I is positively associated with serum prostate-specific antigen in middle-aged men without evidence of prostate cancer.

Journal article

We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.

Authors: Oliver, SE; Barrass, B; Gunnell, D; Donovan, J; Peters, T

• Publication status: Published
• Journal: Cancer epidemiology, biomarkers and prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• Volume: 13
• Issue: 1
• Pages: 163-165
• Publication date: 2004-01-01
• DOI: 10.1158/1055-9965.epi-03-0102
• EISSN: 1538-7755
• ISSN: 1055-9965
• Language: English
• Keywords: Age Distribution; Prostate-Specific Antigen; Insulin-Like Growth Factor I; Humans; Male; Logistic Models; Middle Aged; Prostatic Hyperplasia; Aged