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A robust mass spectrometry method for rapid profiling of erythrocyte ghost membrane proteomes

Abstract:

Background

Red blood cell (RBC) physiology is directly linked to many human disorders associated with low tissue oxygen levels or anemia including chronic obstructive pulmonary disease, congenital heart disease, sleep apnea and sickle cell anemia. Parasites such as Plasmodium spp. and phylum Apicomplexa directly target RBCs, and surface molecules within the RBC membrane are critical for pathogen interactions. Proteomics of RBC membrane ‘ghost’ fractions has therefore been of cons...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12014-018-9190-4

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
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Africa Research Excellence Fund More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Clinical Proteomics Journal website
Volume:
15
Pages:
14
Publication date:
2018-03-21
Acceptance date:
2018-03-13
DOI:
EISSN:
1559-0275
ISSN:
1542-6416
Pubs id:
pubs:831971
URN:
uri:6ae9d8cf-4e06-482a-bd93-730a765f3706
UUID:
uuid:6ae9d8cf-4e06-482a-bd93-730a765f3706
Local pid:
pubs:831971

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