I131-MIBG treatment revisited: How important is scheduling when combined with external beam irradiation?

Corroyer-Dulmont, A; Falzone, N; Able, S; Kersemans, V; Thompson, J; Allen, D; Smart, S; Vallis, K

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I131-MIBG treatment revisited: How important is scheduling when combined with external beam irradiation?

Abstract:: Neuroblastoma is the most frequent extra-cranial tumour in younger childhood. The current treatment of high-risk (stage 4) inoperable neuroblastoma includes a combination of chemotherapy and/or total irradiation with either autologous bone marrow transplantation or peripheral blood stem cell reinfusion. Despite these treatments the 4-year overall survival for high-stage neuroblastoma is still low (69%). Targeted/molecular radiotherapy (MRT) where the overexpressed noradrenaline transporter is targeted with 131I-MIBG (Meta-iodobenzylguanidine) an analogue of noradrenaline is an effective treatment for relapsed or refractory neuroblastoma. The aim of this study is to investigate whether in vivo imaging could be used to inform scheduling of MRT with 131I-MIBG in a human neuroblastoma xenograft model (SK-N-SH) to optimize and enhance the efficacy of external beam irradiation (EBRT).

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Corroyer-Dulmont, A., Falzone, N., Able, S., Kersemans, V., Thompson, J., Allen, D., Smart, S., & Vallis, K. (2016). I131-MIBG treatment revisited: How important is scheduling when combined with external beam irradiation? Journal of Nuclear Medicine, 57(6), *e7677*.

MLA Style

Corroyer-Dulmont, A., et al. “I131-MIBG Treatment Revisited: How Important Is Scheduling When Combined with External Beam Irradiation?” Journal of Nuclear Medicine, vol. 57, no. 6, Society of Nuclear Medicine, 2016, p. *e7677*.

Chicago Style

Corroyer-Dulmont, A, N Falzone, S Able, V Kersemans, J Thompson, D Allen, S Smart, and K Vallis. 2016. “I131-MIBG Treatment Revisited: How Important Is Scheduling When Combined with External Beam Irradiation?” In Journal of Nuclear Medicine, 57:*e7677*. Society of Nuclear Medicine.
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Authors

+ Corroyer-Dulmont, A More by this author

Role:: Author

+ Falzone, N More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: Oncology
Role:: Author

+ Able, S More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: Oncology
Role:: Author

+ Kersemans, V More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: Oncology
Role:: Author

+ Thompson, J More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: Oncology
Role:: Author

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Publisher:: Society of Nuclear Medicine
Host title:: Journal of Nuclear Medicine
Journal:: Journal of Nuclear Medicine More from this journal
Volume:: 57
Issue:: 6
Pages:: *e7677*
Publication date:: 2016-05-01
EISSN:: 1535-5667
ISSN:: 0161-5505

Pubs id:: pubs:917681
UUID:: uuid:6ae95925-9ab5-48bb-baa1-f4299e08e5d4
Local pid:: pubs:917681
Source identifiers:: 917681
Deposit date:: 2018-10-30

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Copyright holder:: Society of Nuclear Medicine and Molecular Imaging
Notes:: Copyright © 2018 Society of Nuclear Medicine and Molecular Imaging. This is the accepted manuscript version of the abstract. The final version is available online from the Society of Nuclear Medicine at: http://jnm.snmjournals.org/content/57/supplement_2/470?related-urls=yes&legid=jnumed;57/supplement_2/470

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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I131-MIBG treatment revisited: How important is scheduling when combined with external beam irradiation?

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