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Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways

Abstract:
Background Recent advances in single-cell techniques have provided the opportunity to finely dissect cellular heterogeneity within populations previously defined by “bulk” assays and to uncover rare cell types. In human hematopoiesis, megakaryocytes and erythroid cells differentiate from a shared precursor, the megakaryocyte-erythroid progenitor (MEP), which remains poorly defined. Results To clarify the cellular pathway in erythro-megakaryocyte differentiat... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13059-016-0939-7

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Funding agency for:
Psaila, B
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Funding agency for:
Psaila, B
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Funding agency for:
Psaila, B
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Publisher:
BioMed Central Publisher's website
Journal:
Genome Biology Journal website
Volume:
17
Issue:
1
Article number:
83
Publication date:
2016-05-01
Acceptance date:
2016-04-08
DOI:
EISSN:
1474-760X
ISSN:
1465-6906
Source identifiers:
614779
Language:
English
Keywords:
Pubs id:
pubs:614779
UUID:
uuid:6add9a33-1ce0-4bfb-9469-e429ba88f3bc
Local pid:
pubs:614779
Deposit date:
2016-05-19

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