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Differential burden of rare and common variants on tumor characteristics, survival, and mode of detection in breast cancer

Abstract:

Genetic variants that increase breast cancer risk can be rare or common. This study tests whether the genetic risk stratification of breast cancer by rare and common variants in established loci can discriminate tumors with different biology, patient survival, and mode of detection. Multinomial logistic regression tested associations between genetic risk load [protein-truncating variant (PTV) carriership in 31 breast cancer predisposition genes—or polygenic risk score (PRS) using 162 single-n...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0001-8587-7511
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Role:
Author
ORCID:
0000-0002-3201-6416
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Oxford college:
University College
Role:
Author
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Role:
Author
ORCID:
0000-0003-4516-7421
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Role:
Author
ORCID:
0000-0001-8135-4270
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Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Research Journal website
Volume:
78
Issue:
21
Pages:
6329-6338
Publication date:
2018-11-01
Acceptance date:
2018-09-26
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Source identifiers:
965426
Language:
English
Pubs id:
pubs:965426
UUID:
uuid:6ad204fa-193d-4d66-9536-c81dcc6932e9
Local pid:
pubs:965426
Deposit date:
2019-01-20

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