Journal article
Mapping the epigenetic modifications of DNA and RNA
- Abstract:
- Over 17 and 160 types of chemical modifications have been identified in DNA and RNA, respectively. The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and epitranscriptomics. Developing chemical and biological tools to detect specific modifications in the genome or transcriptome has greatly facilitated their study. Here, we review the recent technological advances in this rapidly evolving field. We focus on high-throughput detection methods and biological findings for these modifications, and discuss questions to be addressed as well. We also summarize third-generation sequencing methods, which enable long-read and single-molecule sequencing of DNA and RNA modification.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 510.4KB, Terms of use)
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- Publisher copy:
- 10.1007/s13238-020-00733-7
Authors
- Publisher:
- Springer Nature
- Journal:
- Protein and Cell More from this journal
- Volume:
- 11
- Issue:
- 11
- Pages:
- 792–808
- Publication date:
- 2020-05-22
- Acceptance date:
- 2020-03-16
- DOI:
- EISSN:
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1674-8018
- ISSN:
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1674-800X
- Language:
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English
- Keywords:
- Pubs id:
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1095201
- Local pid:
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pubs:1095201
- Deposit date:
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2020-03-19
- ARK identifier:
Terms of use
- Copyright holder:
- Zhao, L et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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