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Embryos of robertsonian translocation carriers exhibit a mitotic interchromosomal effect that enhances genetic instability during early development

Abstract:

Balanced chromosomal rearrangements represent one of the most common forms of genetic abnormality affecting approximately 1 in every 500 (0.2%) individuals. Difficulties processing the abnormal chromosomes during meiosis lead to an elevated risk of chromosomally abnormal gametes, resulting in high rates of miscarriage and/or children with congenital abnormalities. It has also been suggested that the presence of chromosome rearrangements may also cause an increase in aneuploidy affecting struc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1003025

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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS Genetics More from this journal
Volume:
8
Issue:
10
Pages:
ARTN e1003025
Publication date:
2012-10-25
Acceptance date:
2012-08-24
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Language:
English
Keywords:
UUID:
uuid:6ab63270-4455-4da4-84bb-5a16bb1ebd9b
Local pid:
pubs:358508
Source identifiers:
358508
Deposit date:
2013-11-16

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