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Histone modifying and chromatin remodelling enzymes in cancer and dysplastic syndromes.

Abstract:

Inactivation of tumour suppressor genes is central to the development of cancer. Although this inactivation was once considered to be secondary to intragenic mutations, it is now clear that silencing of these genes often occurs by epigenetic means. Hypermethylation of CpG islands associated with the tumour suppressor genes was the first manifestation of this phenomenon to be described. It is apparent, however, that this is one of a host of chromatin modifications which characterize gene silen...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddi106

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Journal:
Human molecular genetics More from this journal
Volume:
14 Spec No 1
Issue:
SPEC. ISS. 1
Pages:
R85-R92
Publication date:
2005-04-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906

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