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Alpha-2-macroglobulin in inflammation, immunity and infections

Abstract:

Alpha-2-macroglobulin is an extracellular macromolecule mainly known for its role as a broad-spectrum protease inhibitor. By presenting itself as an optimal substrate for endopeptidases of all catalytic types, alpha-2-macroglobulin lures active proteases into its molecular cage and subsequently ‘flags’ their complex for elimination. In addition to its role as a regulator of extracellular proteolysis, alpha-2-macroglobulin also has other functions such as switching proteolysis towards small su...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Role:
Author
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
12
Article number:
803244
Publication date:
2021-12-14
Acceptance date:
2021-11-29
DOI:
EISSN:
1664-3224
Language:
English
Keywords:
Pubs id:
1228930
Local pid:
pubs:1228930
Deposit date:
2022-01-04

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