Journal article icon

Journal article

Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin

Abstract:

With functions that range from cell envelope structure to signal transduction and transport, lipoproteins constitute 2 to 3% of bacterial genomes and play critical roles in bacterial physiology, pathogenicity, and antibiotic resistance. Lipoproteins are synthesized with a signal peptide securing them to the cytoplasmic membrane with the lipoprotein domain in the periplasm or outside the cell. Posttranslational processing requires a signal peptidase II (LspA) that removes the signal peptide...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1126/science.aad3747

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Caffrey, M More by this author
Vogeley, L More by this author
El Arnaout, T More by this author
Expand authors...
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Journal website
Volume:
351
Issue:
6275
Pages:
876-880
Publication date:
2016-02-19
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:6a9f0054-fa33-4302-b99d-d72d6014bb93
Source identifiers:
605635
Local pid:
pubs:605635

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP