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Journal article

Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation

Abstract:

Interferon regulating factor 5 (IRF5) is a multifunctional regulator of immune responses, and has a key pathogenic function in gut inflammation, but how IRF5 is modulated is still unclear. Having performed a kinase inhibitor library screening in macrophages, here we identify protein-tyrosine kinase 2-beta (PTK2B/PYK2) as a putative IRF5 kinase. PYK2-deficient macrophages display impaired endogenous IRF5 activation, leading to reduction of inflammatory gene expression. Meanwhile, a PYK2 inhibi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-021-27038-5

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
12
Article number:
6702
Publication date:
2021-11-18
Acceptance date:
2021-10-28
DOI:
ISSN:
2041-1723
Language:
English
Keywords:
Pubs id:
1210483
Local pid:
pubs:1210483
Deposit date:
2021-11-18

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