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Reviews of translational medicine and genomics in cardiovascular disease: new disease taxonomy and therapeutic implications cardiomyopathies: therapeutics based on molecular phenotype.

Abstract:

The enduring subdivision of cardiomyopathies into hypertrophic (HCM), dilated (DCM), and restrictive (RCM) categories reflects the emphasis of traditional classifications on morphology. Rapid advances in the genetic interrogation of these disorders have redefined their taxonomy and revealed potential conflicts between the old and new classifications. Hypertrophic cardiomyopathy has been redefined as a disease of perturbed sarcomere function. Dilated cardiomyopathy is a disease that results fr...

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Publication status:
Published

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Publisher copy:
10.1016/j.jacc.2006.10.073

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Watkins, H More by this author
Journal:
Journal of the American College of Cardiology
Volume:
49
Issue:
12
Pages:
1251-1264
Publication date:
2007-03-05
DOI:
EISSN:
1558-3597
ISSN:
0735-1097
URN:
uuid:6a8d85d8-5207-4171-ac36-1d51e1d9add5
Source identifiers:
104232
Local pid:
pubs:104232

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