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Reviews of translational medicine and genomics in cardiovascular disease: new disease taxonomy and therapeutic implications cardiomyopathies: therapeutics based on molecular phenotype.

Abstract:

The enduring subdivision of cardiomyopathies into hypertrophic (HCM), dilated (DCM), and restrictive (RCM) categories reflects the emphasis of traditional classifications on morphology. Rapid advances in the genetic interrogation of these disorders have redefined their taxonomy and revealed potential conflicts between the old and new classifications. Hypertrophic cardiomyopathy has been redefined as a disease of perturbed sarcomere function. Dilated cardiomyopathy is a disease that results fr...

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Publication status:
Published

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Publisher copy:
10.1016/j.jacc.2006.10.073

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Journal:
Journal of the American College of Cardiology
Volume:
49
Issue:
12
Pages:
1251-1264
Publication date:
2007-03-01
DOI:
EISSN:
1558-3597
ISSN:
0735-1097
Source identifiers:
104232
Language:
English
Keywords:
Pubs id:
pubs:104232
UUID:
uuid:6a8d85d8-5207-4171-ac36-1d51e1d9add5
Local pid:
pubs:104232
Deposit date:
2012-12-19

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