Journal article : Review

Synthesis of heterobicyclo[ n.1.1]alkanes

Abstract:: Heterocyclic bicyclo[n.1.1]alkanes have emerged as important scaffolds in contemporary drug design due to their rigid frameworks that enable the positioning of their subsituents along well defined vectors in chemical space. Offering much potential as alternative cores to traditional benzene rings, heterobicyclo[2.1.1]hexanes (HBCHexs) and heterobicyclo[3.1.1]heptanes (HBCHeps) in particular have attracted significant attention from the synthetic community. A plethora of methods have recently been developed to access these useful motifs, using both radical and polar strategies to forge the bicyclic system. This review discusses recent developments in the field, with a focus on mechanistic aspects, and those methodologies that show the most potential for general application.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Revie, R. I., Ragus, J., & Anderson, E. A. (2025). Synthesis of heterobicyclo[ n.1.1]alkanes. Chemical Society Reviews.

MLA Style

Revie, RI, et al. “Synthesis of Heterobicyclo[ N.1.1]Alkanes.” Chemical Society Reviews, 2025.

Chicago Style

Revie, RI, J Ragus, and EA Anderson. 2025. “Synthesis of Heterobicyclo[ N.1.1]Alkanes.” Chemical Society Reviews.
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Files:: Revie_et_al_2025_Synthesis_of_heterobicyclo[.pdf

(Preview, Version of record, pdf, 4.2MB, Terms of use)

Publisher copy:: 10.1039/d5cs01128k

Authors

+ Revie, RI More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Chemistry Research Laboratory
Role:: Author
ORCID:: 0009-0009-2834-8758

+ Ragus, J More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Chemistry Research Laboratory
Role:: Author
ORCID:: 0009-0005-3375-206X

+ Anderson, EA More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Chemistry Research Laboratory
Role:: Author
ORCID:: 0000-0002-4149-0494

+ Engineering and Physical Sciences Research Council More from this funder

Funder identifier:: https://ror.org/0439y7842

Publisher:: Royal Society of Chemistry
Journal:: Chemical Society Reviews More from this journal
Publication date:: 2025-12-17
DOI:: 10.1039/d5cs01128k
EISSN:: 1460-4744
ISSN:: 0306-0012

Language:: English
Subtype:: Review
Pubs id:: 2353262
UUID:: uuid_6a8d804c-8d79-40f6-8eb7-1eedab1de81f
Local pid:: pubs:2353262
Source identifiers:: 3572030
Deposit date:: 2025-12-17
ARK identifier:: ark:/29072/ora_6a8d804c8d7940f68eb71eedab1de81f

Terms of use

Copyright date:: 2025

Licence:: CC Attribution (CC BY) 3.0

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