Journal article
Tumor imaging using radiolabelled matrix metalloproteinase-activated anthrax proteins
- Abstract:
-
Purpose: Increased activity of matrix metalloproteinases (MMPs) is associated with worse prognosis in different cancer types. The protective antigen (PA-WT) of the binary anthrax lethal toxin was modified to form a pore in cell membranes only when cleaved by MMPs (PA-L1). Anthrax lethal factor (LF) is then able to translocate through these pores. Here, we used an 111In-radiolabelled form of LF with the PA/LF system for non-invasive in vivo imaging of MMP activit...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Pancreatic Cancer UK
More from this funder
Bibliographic Details
- Publisher:
- Society of Nuclear Medicine and Molecular Imaging Publisher's website
- Journal:
- Journal of Nuclear Medicine Journal website
- Volume:
- 60
- Issue:
- 10
- Pages:
- 1474–1482
- Publication date:
- 2019-04-06
- Acceptance date:
- 2019-03-13
- DOI:
- EISSN:
-
2159-662X
- ISSN:
-
0161-5505
Item Description
- Keywords:
- Pubs id:
-
pubs:982596
- UUID:
-
uuid:6a83a897-50df-4de6-9db0-cfd7b335a27f
- Local pid:
- pubs:982596
- Deposit date:
- 2019-03-14
Terms of use
- Copyright holder:
- Society of Nuclear Medicine and Molecular Imaging
- Copyright date:
- 2019
- Notes:
- Copyright © 2019 by the Society of Nuclear Medicine and Molecular Imaging, Inc. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record