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Long-read whole genome sequencing and comparative analysis of six strains of the human pathogen Orientia tsutsugamushi

Abstract:

Background:
Orientia tsutsugamushi is a clinically important but neglected obligate intracellular bacterial pathogen of the Rickettsiaceae family that causes the potentially life-threatening human disease scrub typhus. In contrast to the genome reduction seen in many obligate intracellular bacteria, early genetic studies of Orientia have revealed one of the most repetitive bacterial genomes sequenced to date. The dramatic expansion of mobile elements has hampered eff...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1101/280958

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
ORCID:
0000-0001-8559-452X
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Name:
Royal Society
Grant:
DH140154
Publisher:
Public Library of Science
Journal:
PLoS Neglected Tropical Diseases More from this journal
Volume:
12
Issue:
6
Article number:
e0006566
Publication date:
2018-06-06
Acceptance date:
2018-05-28
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
Language:
English
Keywords:
Pubs id:
998360
Local pid:
pubs:998360
Deposit date:
2020-06-02

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