Journal article
An autonomous molecular assembler for programmable chemical synthesis
- Abstract:
- Molecular machines that assemble polymers in a programmed sequence are fundamental to life. They are also an achievable goal of nanotechnology. Here, we report synthetic molecular machinery made from DNA which controls and records the formation of covalent bonds. We show that an autonomous cascade of DNA hybridization reactions can create oligomers, from building blocks linked by olefin or peptide bonds, with a sequence defined by a reconfigurable molecular program. The system can also be programmed to achieve combinatorial assembly. The sequence of assembly reactions, and thus the structure, of each oligomer synthesized is recorded in a DNA molecule which enables this information to be recovered by PCR amplification followed by DNA sequencing.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
+ Royal Society
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- Funding agency for:
- Turberfield, A
- Grant:
- Wolfson Research Merit Award
- Wolfson Research Merit Award
+ Engineering and Physical Sciences Research Council
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- Grant:
- EP/F056605/1, EP/F008597/1, EP/I016651/1, EP/F055803/1, EP/F009062/1, EP/G037930/1, EP/P504287/1
+ Biology and Biotechnology Research Council
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- Grant:
- sLOLA grant BB/J00054X/1, BB/J001694/2
- Publisher:
- Nature Publishing Group
- Journal:
- Nature Chemistry More from this journal
- Publication date:
- 2016-01-01
- Acceptance date:
- 2016-03-11
- DOI:
- EISSN:
-
1755-4349
- ISSN:
-
1755-4330
- Pubs id:
-
pubs:609668
- UUID:
-
uuid:6a31fad2-cb43-4e75-a9ba-7bfd02cdbfe9
- Local pid:
-
pubs:609668
- Source identifiers:
-
609668
- Deposit date:
-
2016-03-11
Terms of use
- Copyright holder:
- Meng et al
- Copyright date:
- 2016
- Notes:
- This paper has been accepted for publication in Nature Chemistry.
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