Journal article icon

Journal article

An autonomous molecular assembler for programmable chemical synthesis

Abstract:

Molecular machines that assemble polymers in a programmed sequence are fundamental to life. They are also an achievable goal of nanotechnology. Here, we report synthetic molecular machinery made from DNA which controls and records the formation of covalent bonds. We show that an autonomous cascade of DNA hybridization reactions can create oligomers, from building blocks linked by olefin or peptide bonds, with a sequence defined by a reconfigurable molecular program. The system can also be pro...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1038/NChem.2495

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More from this funder
Name:
Royal Society
Funding agency for:
Turberfield, A
Grant:
Wolfson Research Merit Award
Wolfson Research Merit Award
More from this funder
Name:
Engineering and Physical Sciences Research Council
Grant:
EP/F056605/1, EP/F008597/1, EP/I016651/1, EP/F055803/1, EP/F009062/1, EP/G037930/1, EP/P504287/1
More from this funder
Name:
Biology and Biotechnology Research Council
Grant:
sLOLA grant BB/J00054X/1, BB/J001694/2
Publisher:
Nature Publishing Group
Journal:
Nature Chemistry More from this journal
Publication date:
2016-01-01
Acceptance date:
2016-03-11
DOI:
EISSN:
1755-4349
ISSN:
1755-4330
Pubs id:
pubs:609668
UUID:
uuid:6a31fad2-cb43-4e75-a9ba-7bfd02cdbfe9
Local pid:
pubs:609668
Source identifiers:
609668
Deposit date:
2016-03-11

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP