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Thesis

Cytokine and growth factor regulation of murine macrophage scavenger receptor expression and function

Abstract:

The macrophage (Mφ) foam cell in the atherosclerotic plaque microenvironment is subjected to cytokines and growth factors secreted by smooth muscle cells (SMCs), endothelial cells (ECs), platelets and lesional Mφ themselves. This thesis examines the effects of some of these soluble factors on a murine macrophage membrane molecule, the macrophage scavenger receptor (MSR), considered pivotal in foam cell formation and atherogenesis. Macrophage Colony-stimulating factor (MCSF) enhances MSR e...

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Institution:
University of Oxford
Division:
MSD
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
1995
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Source identifiers:
602801752
Language:
English
Subjects:
UUID:
uuid:6a237f16-92b0-471e-bcef-d8a316ebc6b0
Local pid:
td:602801752
Deposit date:
2014-04-01

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