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Evolutionary relationships and protein domain architecture in an expanded calpain superfamily in kinetoplastid parasites.

Abstract:

Employing whole-genome analysis we have characterized a large family of genes coding for calpain-related proteins in three kinetoplastid parasites. We have defined a total of 18 calpain-like sequences in Trypanosoma brucei, 27 in Leishmania major, and 24 in Trypanosoma cruzi. Sequence characterization revealed a well-conserved protease domain in most proteins, although residues critical for catalytic activity were frequently altered. Many of the proteins contain a novel N-terminal sequence mo...

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Publication status:
Published

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Publisher copy:
10.1007/s00239-004-0272-8

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of molecular evolution More from this journal
Volume:
61
Issue:
6
Pages:
742-757
Publication date:
2005-12-01
DOI:
EISSN:
1432-1432
ISSN:
0022-2844
Language:
English
Keywords:
Pubs id:
pubs:26405
UUID:
uuid:6a20e6ff-7bbb-48cf-8f31-01dd1eb3f89d
Local pid:
pubs:26405
Source identifiers:
26405
Deposit date:
2012-12-19

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