Journal article

Peptidic Catalysts Conformationally Tuned for Fluoride Binding and Delivery

Abstract:: Knowledge on how fluoride interacts with peptides is currently limited to in silico studies. Here, we report an experimental investigation on the ability of peptidic scaffolds to bind fluoride using TBAF·3H2O or CsF. For CsF, in-depth NMR and GOAT-DFT studies shed light on peptides acting as chelators to both fluoride and cesium ions. This finding led to the development of the first peptide-catalyzed fluorination reactions. These advances open a new avenue to investigate fluorination chemistry with peptide-based catalysts that are considered as the possible ancestors to enzymes.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Poškaitė, G., Schlatzer, T., Chen, Z., Popescu, M. V., Paton, R. S., & Gouverneur, V. (2026). Peptidic Catalysts Conformationally Tuned for Fluoride Binding and Delivery. Journal of the American Chemical Society, 148(9), 9238–9243.

MLA Style

Poškaitė, G, et al. “Peptidic Catalysts Conformationally Tuned for Fluoride Binding and Delivery.” Journal of the American Chemical Society, vol. 148, no. 9, 2026, pp. 9238–43.

Chicago Style

Poškaitė, G, T Schlatzer, Z Chen, MV Popescu, RS Paton, and V Gouverneur. 2026. “Peptidic Catalysts Conformationally Tuned for Fluoride Binding and Delivery.” Journal of the American Chemical Society 148 (9): 9238–43.
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Files:: Poskaite_et_al_2026_Peptidic_Catalysts_Conformationally.pdf

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Publisher copy:: 10.1021/jacs.6c01667

Authors

+ Poškaitė, G More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Chemistry Research Laboratory
Role:: Author
ORCID:: 0000-0002-6529-907X

+ Schlatzer, T More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Chemistry Research Laboratory
Role:: Author
ORCID:: 0000-0001-5034-0968

+ Chen, Z More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Chemistry Research Laboratory
Role:: Author

+ Popescu, MV More by this author

Role:: Author

+ Paton, RS More by this author

Role:: Author
ORCID:: 0000-0002-0104-4166

More authors...

+ Division of Chemistry More from this funder

Funder identifier:: https://ror.org/01ar8dr59
Grant:: CHE-2400056

+ European Research Council More from this funder

Funder identifier:: https://ror.org/0472cxd90
Grant:: 832994

+ Engineering and Physical Sciences Research Council More from this funder

Funder identifier:: https://ror.org/0439y7842
Grant:: APP17346

+ Austrian Science Fund More from this funder

Funder identifier:: 10.13039/501100002428
Grant:: J 4705

Publisher:: American Chemical Society
Journal:: Journal of the American Chemical Society More from this journal
Volume:: 148
Issue:: 9
Pages:: 9238-9243
Publication date:: 2026-02-24
Acceptance date:: 2026-02-20
DOI:: 10.1021/jacs.6c01667
EISSN:: 1520-5126
ISSN:: 0002-7863

Language:: English
Keywords:: Fluoride

Catalysis

Peptide

Caesium

Fluorine
Pubs id:: 2384429
Local pid:: pubs:2384429
Source identifiers:: 3846014
Deposit date:: 2026-03-12
ARK identifier:: ark:/29072/ora_6a1467405b594d649db6d0a17c56246f

Terms of use

Copyright date:: 2026

Licence:: CC Attribution (CC BY)

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