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Horizontally acquired AT-rich genes in Escherichia coli cause toxicity by sequestering RNA polymerase

Abstract:

Horizontal gene transfer permits rapid dissemination of genetic elements between individuals in bacterial populations. Transmitted DNA sequences may encode favourable traits. However, if the acquired DNA has an atypical base composition, it can reduce host fitness. Consequently, bacteria have evolved strategies to minimize the harmful effects of foreign genes. Most notably, xenogeneic silencing proteins bind incoming DNA that has a higher AT content than the host genome. An enduring question ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/nmicrobiol.2016.249

Authors


Lamberte, LE More by this author
Baniulyte, G More by this author
Stringer, AM More by this author
Bonocora, RP More by this author
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Funding agency for:
Kapanidis, AN
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Grant:
project grant (RPG-2013-147) to DCG
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Grant:
Career Development Fellowship (WT085092MA) awarded to D.C.G.
Publisher:
Springer Nature Publisher's website
Journal:
Nature Microbiology Journal website
Volume:
2
Issue:
3
Pages:
Article: 16249
Publication date:
2017-01-09
Acceptance date:
2016-10-21
DOI:
ISSN:
2058-5276
Pubs id:
pubs:670917
URN:
uri:69f8e4b2-8941-4b5e-a974-21ee36c22add
UUID:
uuid:69f8e4b2-8941-4b5e-a974-21ee36c22add
Local pid:
pubs:670917
Language:
English

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