Matrix remodelling enzymes, the protease cascade and glycosylation.

Journal article

Glycosylation influences the specific activities of serine proteases including tissue-type plasminogen activator and plasmin which act together in a ternary complex with fibrin. Serine proteases and matrix metalloproteinases (MMPs), including gelatinase B, participate in a protease cascade to remodel the extracellular matrix. In addition to the recognition and targeting functions of carbohydrates and the fact that they confer protease resistance on glycoproteins, oligosaccharides may extend p...

Expand abstract

Authors: Van den Steen, P; Opdenakker, G; Wormald, M; Dwek, R; Rudd, P

• Publication status: Published
• Journal: Biochimica et biophysica acta
• Volume: 1528
• Issue: 2-3
• Pages: 61-73
• Publication date: 2001-10-01
• DOI: 10.1016/S0304-4165(01)00190-8
• ISSN: 0006-3002
• Language: English
• Keywords: Protein Structure, Tertiary; Matrix Metalloproteinase 9; Polysaccharides; Animals; Protein Conformation; Enzyme Activation; Extracellular Matrix; Matrix Metalloproteinases; Glycosylation; Humans; Models, Molecular; Serine Endopeptidases