Journal article
Membrane applications in autologous cell therapy
- Abstract:
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Stem cell and cell therapies, particularly autologous cell therapies, are becoming a common practice. However, in order for these technologies to achieve wide-scale clinical application, the prohibitively high cost associated with these therapies must be addressed through creative engineering. Membranes can be a disruptive technology to reshape the bioprocessing and manufacture of cellular products and significantly reduce the cost of autologous cell therapies. Examples of successful membrane applications include expansions of CAR-T cells, various human stem cells, and production of extracellular vesicles (EVs) using hollow fibre membrane bioreactors. Novel membranes with tailored functions and surface properties and novel membrane modules that can accommodate the changing needs for surface area and transport properties are to be developed to fulfil this key role.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Preview, Version of record, pdf, 1.9MB, Terms of use)
-
- Publisher copy:
- 10.3390/membranes12121182
Authors
- Publisher:
- MDPI
- Journal:
- Membranes More from this journal
- Volume:
- 12
- Issue:
- 12
- Article number:
- 1182
- Publication date:
- 2022-11-24
- Acceptance date:
- 2022-11-07
- DOI:
- EISSN:
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2077-0375
- Language:
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English
- Keywords:
- Pubs id:
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1312178
- Local pid:
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pubs:1312178
- Deposit date:
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2022-12-09
Terms of use
- Copyright holder:
- Martin et al.
- Copyright date:
- 2022
- Rights statement:
- © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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