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Journal article

Controversies and priorities in amyotrophic lateral sclerosis.

Abstract:

Two decades after the discovery that 20% of familial amyotrophic lateral sclerosis (ALS) cases were linked to mutations in the superoxide dismutase-1 (SOD1) gene, a substantial proportion of the remainder of cases of familial ALS have now been traced to an expansion of the intronic hexanucleotide repeat sequence in C9orf72. This breakthrough provides an opportunity to re-evaluate longstanding concepts regarding the cause and natural history of ALS, coming soon after the pathological unificati...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
The Lancet. Neurology
Volume:
12
Issue:
3
Pages:
310-322
Publication date:
2013-03-05
DOI:
EISSN:
1474-4465
ISSN:
1474-4422
URN:
uuid:69e84c9f-8155-4e83-8fa1-f69be42fef6f
Source identifiers:
387128
Local pid:
pubs:387128
Language:
English
Keywords:

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