- Abstract:
-
Two decades after the discovery that 20% of familial amyotrophic lateral sclerosis (ALS) cases were linked to mutations in the superoxide dismutase-1 (SOD1) gene, a substantial proportion of the remainder of cases of familial ALS have now been traced to an expansion of the intronic hexanucleotide repeat sequence in C9orf72. This breakthrough provides an opportunity to re-evaluate longstanding concepts regarding the cause and natural history of ALS, coming soon after the pathological unificati...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s1474-4422(13)70036-x
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- Journal:
- The Lancet. Neurology
- Volume:
- 12
- Issue:
- 3
- Pages:
- 310-322
- Publication date:
- 2013-03-05
- DOI:
- EISSN:
-
1474-4465
- ISSN:
-
1474-4422
- URN:
-
uuid:69e84c9f-8155-4e83-8fa1-f69be42fef6f
- Source identifiers:
-
387128
- Local pid:
- pubs:387128
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Controversies and priorities in amyotrophic lateral sclerosis.
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