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Tissue plasminogen activator does not increase neuronal damage in rat models of global and focal ischemia.

Abstract:

BACKGROUND: Intravenous tissue plasminogen activator (tPA) is the only approved treatment for acute ischemic stroke. Recent results from both in vitro and in vivo animal model experiments suggest the possibility that tPA is neurotoxic. METHODS: The authors evaluated the putative neurotoxicity of tPA in both global and focal animal models of ischemic stroke. Global ischemia was induced in male Wistar rats using a modified four-vessel occlusion technique, with percentage neuronal injury assesse...

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Publication status:
Published

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Publisher copy:
10.1212/wnl.52.7.1381

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Stroke and Geratology
Role:
Author
Journal:
Neurology
Volume:
52
Issue:
7
Pages:
1381-1384
Publication date:
1999-04-01
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
Source identifiers:
79124
Language:
English
Keywords:
Pubs id:
pubs:79124
UUID:
uuid:69e57874-8a9c-4094-9e5d-62ba66414826
Local pid:
pubs:79124
Deposit date:
2012-12-19

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