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Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo.

Abstract:

Regulatory T cells (T(reg)) are currently being tested in clinical trials as a potential therapy in cell and solid organ transplantation. The immunosuppressive drug rapamycin has been shown to preferentially promote T(reg) expansion. Here, we hypothesized that adjunctive rapamycin therapy might potentiate the ability of ex vivo expanded human T(reg) to inhibit vascular allograft rejection in a humanized mouse model of arterial transplantation. We studied the influence of combined treatment wi...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
Am J Transplant More from this journal
Volume:
12
Issue:
8
Pages:
2008-2016
Publication date:
2012-08-01
DOI:
EISSN:
1600-6143
ISSN:
1600-6135
Language:
English
Keywords:
Pubs id:
pubs:325170
UUID:
uuid:69e3188b-eee5-4033-b897-9e47af765ea8
Local pid:
pubs:325170
Source identifiers:
325170
Deposit date:
2013-11-17

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