Journal article
Pancreatic β-cell electrical activity and insulin secretion: of mice and men
- Abstract:
-
The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only hormone capable of lowering the blood glucose concentration. Impaired insulin secretion results in the chronic hyperglycemia that characterizes type 2 diabetes (T2DM), which currently afflicts >450 million people worldwide. The healthy β-cell acts as a glucose sensor matching its output to the circulating glucose concentration. It does so via metabolically induced changes in electrical activity, wh...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Swedish Research Council
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Diabetes UK
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Bibliographic Details
- Publisher:
- American Physiological Society Publisher's website
- Journal:
- Physiological reviews Journal website
- Volume:
- 98
- Issue:
- 1
- Pages:
- 117-214
- Publication date:
- 2017-12-06
- Acceptance date:
- 2017-06-18
- DOI:
- EISSN:
-
1522-1210
- ISSN:
-
0031-9333
- Pmid:
-
29212789
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:809895
- UUID:
-
uuid:69dbc350-8280-4084-b6b5-547534a0b338
- Local pid:
- pubs:809895
- Source identifiers:
-
809895
- Deposit date:
- 2018-02-02
Terms of use
- Copyright holder:
- © 2018 the American Physiological Society
- Copyright date:
- 2017
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