Journal article icon

Journal article

Pancreatic β-cell electrical activity and insulin secretion: of mice and men

Abstract:

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only hormone capable of lowering the blood glucose concentration. Impaired insulin secretion results in the chronic hyperglycemia that characterizes type 2 diabetes (T2DM), which currently afflicts >450 million people worldwide. The healthy β-cell acts as a glucose sensor matching its output to the circulating glucose concentration. It does so via metabolically induced changes in electrical activity, wh...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1152/physrev.00008.2017

Authors


More by this author
Role:
Author
ORCID:
0000-0001-7578-0767
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
ORCID:
0000-0002-6970-1767
More from this funder
Name:
Royal Society
Grant:
322620;
More from this funder
Name:
European Research Council
Grant:
322620
More from this funder
Name:
Wellcome Trust
Grant:
084655
Publisher:
American Physiological Society
Journal:
Physiological reviews More from this journal
Volume:
98
Issue:
1
Pages:
117-214
Publication date:
2017-12-06
Acceptance date:
2017-06-18
DOI:
EISSN:
1522-1210
ISSN:
0031-9333
Pmid:
29212789
Language:
English
Keywords:
Pubs id:
pubs:809895
UUID:
uuid:69dbc350-8280-4084-b6b5-547534a0b338
Local pid:
pubs:809895
Source identifiers:
809895
Deposit date:
2018-02-02

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP