Journal article

Studies towards the synthesis of the antibiotic tetrodecamycin

Abstract:: A study towards the natural product tetrodecamycin is reported. A modified Schlosser–Wittig reaction was utilized to prepare the precursor for the subsequent intramolecular Diels–Alder reaction, which delivered the trans-decalin ring of the natural product. The tetronic acid moiety of the molecule was prepared by a Dieckmann cyclization. The cyclization of the tetronic acid to the trans-decalin double bond to form a seven-membered ring was examined.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Lee, V., He, J., & Baldwin, J. (2018). Studies towards the synthesis of the antibiotic tetrodecamycin. Synlett, 29(08), 1117–1121.

MLA Style

Lee, V., et al. “Studies towards the Synthesis of the Antibiotic Tetrodecamycin.” Synlett, vol. 29, no. 08, Thieme Publishing, 2018, pp. 1117–21.

Chicago Style

Lee, V, J He, and J Baldwin. 2018. “Studies towards the Synthesis of the Antibiotic Tetrodecamycin.” Synlett 29 (08): 1117–21.
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Files:: Jing's Synlett.pdf

(Preview, Accepted manuscript, pdf, 1.6MB, Terms of use)

Publisher copy:: 10.1055/s-0037-1609303

Authors

+ Lee, V More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Oxford college:: Oriel College
Role:: Author
ORCID:: 0000-0002-4032-6481

+ He, J More by this author

Role:: Author

+ Baldwin, J More by this author

Role:: Author

Publisher:: Thieme Publishing
Journal:: Synlett More from this journal
Volume:: 29
Issue:: 08
Pages:: 1117-1121
Publication date:: 2018-03-16
Acceptance date:: 2018-01-19
DOI:: 10.1055/s-0037-1609303
EISSN:: 1437-2096
ISSN:: 0936-5214

Language:: English
Keywords:: Dieckmann cyclization

intramolecular Diels-Alder reaction

aldol reaction

FFR

Schlosser-Wittig reaction

tetronic acid
Pubs id:: pubs:832437
UUID:: uuid:69d8fdc6-71da-4c04-a292-d53ee2dc5991
Local pid:: pubs:832437
Source identifiers:: 832437
Deposit date:: 2019-11-05

Terms of use

Copyright holder:: Georg Thieme Verlag Stuttgart · New York
Copyright date:: 2018
Notes:: © Georg Thieme Verlag Stuttgart · New York. This is the accepted manuscript version of the article. The final version is available online from Thieme Publishing at: https://doi.org/10.1055/s-0037-1609303

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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