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Journal article

Initiation and promotion at different ages and doses in 2200 mice. I. Methods, and the apparent persistence of initiated cells.

Abstract:

Delay between initiation and promotion on mouse skin was in 1949 reported by Berenblum and Shubik not to affect tumour yields, and this led to the important concept of the irreversibility of initiation and stimulated the development of multistage models. Subsequent reports have, however, suggested that delay does decrease tumour yields, and this is confirmed by the present study of 2200 mice initiated at 8, 48, or 68 weeks with 10, 30, 100, or 300 microgram of DMBA and promoted by a standard ...

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Publication status:
Published

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Publisher copy:
10.1038/bjc.1981.141

Authors


Stenbäck, F More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Journal:
British journal of cancer
Volume:
44
Issue:
1
Pages:
1-14
Publication date:
1981-07-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:69cbdf43-4fe4-40eb-bfb4-89599215e0f7
Source identifiers:
79624
Local pid:
pubs:79624

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