- Abstract:
-
Delay between initiation and promotion on mouse skin was in 1949 reported by Berenblum and Shubik not to affect tumour yields, and this led to the important concept of the irreversibility of initiation and stimulated the development of multistage models. Subsequent reports have, however, suggested that delay does decrease tumour yields, and this is confirmed by the present study of 2200 mice initiated at 8, 48, or 68 weeks with 10, 30, 100, or 300 microgram of DMBA and promoted by a standard ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/bjc.1981.141
-
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- Journal:
- British journal of cancer
- Volume:
- 44
- Issue:
- 1
- Pages:
- 1-14
- Publication date:
- 1981-07-05
- DOI:
- EISSN:
-
1532-1827
- ISSN:
-
0007-0920
- URN:
-
uuid:69cbdf43-4fe4-40eb-bfb4-89599215e0f7
- Source identifiers:
-
79624
- Local pid:
- pubs:79624
- Copyright date:
- 1981
Journal article
Initiation and promotion at different ages and doses in 2200 mice. I. Methods, and the apparent persistence of initiated cells.
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