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IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis

Abstract:

Mycobacterium tuberculosis (Mtb) is a life-threatening pathogen in humans. Bacterial infection of macrophages usually triggers strong innate immune mechanisms, including IL-1 cytokine secretion. The newer member of the IL-1 family, IL-36, was recently shown to be involved in cellular defense against Mtb. To unveil the underlying mechanism of IL-36 induced antibacterial activity, we analyzed its role in the regulation of cholesterol metabolism, together with the involvement of Liver X Receptor...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41598-018-19476-x

Authors


Maertzdorf, J More by this author
Guhlich-Bornhof, U More by this author
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ORCID:
0000-0001-9866-8268
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
ORCID:
0000-0003-4337-9113
Max Planck Society More from this funder
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Grant:
HEALTH-F4-2011-280873
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Pages:
Article: 1520
Publication date:
2018-01-24
Acceptance date:
2017-12-27
DOI:
EISSN:
2045-2322
Pubs id:
pubs:939832
URN:
uri:69c88c8c-c42d-49fb-9b31-f2a2073ac8d7
UUID:
uuid:69c88c8c-c42d-49fb-9b31-f2a2073ac8d7
Local pid:
pubs:939832
Language:
English

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