- Abstract:
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Mycobacterium tuberculosis (Mtb) is a life-threatening pathogen in humans. Bacterial infection of macrophages usually triggers strong innate immune mechanisms, including IL-1 cytokine secretion. The newer member of the IL-1 family, IL-36, was recently shown to be involved in cellular defense against Mtb. To unveil the underlying mechanism of IL-36 induced antibacterial activity, we analyzed its role in the regulation of cholesterol metabolism, together with the involvement of Liver X Receptor...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
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(pdf, 6.1mb)
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- Publisher copy:
- 10.1038/s41598-018-19476-x
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 8
- Pages:
- Article: 1520
- Publication date:
- 2018-01-24
- Acceptance date:
- 2017-12-27
- DOI:
- EISSN:
-
2045-2322
- Pubs id:
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pubs:939832
- URN:
-
uri:69c88c8c-c42d-49fb-9b31-f2a2073ac8d7
- UUID:
-
uuid:69c88c8c-c42d-49fb-9b31-f2a2073ac8d7
- Local pid:
- pubs:939832
- Language:
- English
- Copyright holder:
- Ahsan et al.
- Copyright date:
- 2018
- Notes:
- © The Authors 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Journal article
IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis
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