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The interferon-dependent orchestration of innate and adaptive immunity after transplantation.

Abstract:

The therapeutic GVL effect after allogeneic stem cell transplantation is limited by the development of GVHD. The ultimate aim of current research is to separate the 2 processes in a meaningful fashion. The IFNs are a pleiotropic group of cytokines that were originally recognized because of their ability to interfere with viral replication. However, it is now established that these cytokines play an important role in orchestrating both innate and adaptive immunity. Multiple studies have invest...

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Journal:
Blood
Volume:
119
Issue:
23
Pages:
5351-5358
Publication date:
2012-06-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
400737
Language:
English
Keywords:
Pubs id:
pubs:400737
UUID:
uuid:69c59a58-35f4-4273-bef3-0867c835864d
Local pid:
pubs:400737
Deposit date:
2013-11-16

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