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Identification of a cryptic bacterial promoter in mouse (mdr1a) P-glycoprotein cDNA

Abstract:

The efflux transporter P-glycoprotein (P-gp) is an important mediator of various pharmacokinetic parameters, being expressed at numerous physiological barriers and also in multidrug-resistant cancer cells. Molecular cloning of homologous cDNAs is an important tool for the characterization of functional differences in P-gp between species. However, plasmids containing mouse mdr1a cDNA display significant genetic instability during cloning in bacteria, indicating that mdr1a cDNA may be somehow ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0136396

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Name:
National Institutes of Health
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
10
Issue:
8
Article number:
e0136396
Publication date:
2015-08-26
Acceptance date:
2015-08-03
DOI:
EISSN:
1932-6203
Language:
English
Pubs id:
pubs:572241
UUID:
uuid:69b1616d-b45d-4d5e-a435-f4e92dd1c46e
Local pid:
pubs:572241
Source identifiers:
572241
Deposit date:
2015-11-12

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