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Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas.

Abstract:

Hormones such as glucagon are secreted by Ca(2+)-induced exocytosis of large dense-core vesicles, but the mechanisms involved have only been partially elucidated. Studies of pancreatic beta-cells secreting insulin revealed that synaptotagmin-7 alone is not sufficient to mediate Ca(2+)-dependent insulin granule exocytosis, and studies of chromaffin cells secreting neuropeptides and catecholamines showed that synaptotagmin-1 and -7 collaborate as Ca(2+) sensors for exocytosis, and that both are...

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Publication status:
Published

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Journal:
Journal of physiology More from this journal
Volume:
587
Issue:
Pt 6
Pages:
1169-1178
Publication date:
2009-03-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Language:
English
Keywords:
Pubs id:
pubs:14776
UUID:
uuid:69aee79c-04e0-47cf-8115-ca025a58a66f
Local pid:
pubs:14776
Source identifiers:
14776
Deposit date:
2013-09-17

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